Background/Literature

Publications connected to the PASTA trial

• Delphi Process: Steinlin M, O’callaghan F, Mackay MT. Planning interventional trials in childhood arterial ischaemic stroke using a Delphi consensus process. Dev Med Child Neurol. 2017;59(7):713-718. doi:10.1111/dmcn.13393; https://onlinelibrary.wiley.com/doi/10.1111/dmcn.13393
• Study protocol: Brechbühl et al. High Dose Steroids in Children with Stroke and Unilateral Focal Arteriopathy: A Multicenter Randomized Controlled Trial; Pediatr Stroke. 2023;6: 21-42; https://pediatricstrokejournal.com/high-dose-steroids-in-children-with-stroke-and-unilateral-focal-arteriopathy-a-multicenter-randomized-controlled-trial/

Important Background Literature

• Definition of FCA Braun, K P J et al. “The course and outcome of unilateral intracranial arteriopathy in 79 children with ischaemic stroke.” Brain : a journal of neurology vol. 132,Pt 2 (2009): 544-57. doi:10.1093/brain/awn313
• Pathogenesis: Cornet, Marie-Coralie et al. “The Role of Infection and Inflammation in the Pathogenesis of Pediatric Arterial Ischemic Stroke.” Seminars in Pediatric Neurology vol. 44 (2022). doi:10.1016/j.spen.2022.100995
• Definition of FCA: Dlamini, Nomazulu et al. “Intracranial dissection mimicking transient cerebral arteriopathy in childhood arterial ischemic stroke.” Journal of child neurology vol. 26,9 (2011): 1203-6. doi:10.1177/0883073811408904
• Focal Cerebral Arteriopathy Severity Score: Fullerton, Heather J et al. “Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History.” Stroke vol. 49,11 (2018): 2590-2596. doi:10.1161/STROKEAHA.118.021556
• Focal Cerebral Arteriopathy Severity Score: Slavova, Nedelina et al. “Validation of the focal cerebral arteriopathy severity score (FCASS) in a Swiss cohort: Correlation with infarct volume and outcome.” European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society vol. 28 (2020): 58-63. doi:10.1016/j.ejpn.2020.07.015
• Steroid treatment: Steinlin, Maja et al. “Focal Cerebral Arteriopathy: Do Steroids Improve Outcome?.” Stroke vol. 48,9 (2017): 2375-2382. doi:10.1161/STROKEAHA.117.016818

Local Bernese Stroke Guidelines

Bernese Stroke Guidelines

Swiss Neuro Paediatric Stroke Registry